ESS2

Across TCGA cell cohorts, ESS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,409 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ESS2-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cellular anatomical structure, Symbiont-mediated disruption of host anatomical structure, and Interleukin-34-mediated signaling pathway. Each is linked with ESS2 in more than 17 cancer types. Because this analysis shows association rather than direction, both ESS2-to-partner and partner-to-ESS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cellular anatomical structure grouped by ESS2-low versus ESS2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ESS2→partner) and Y-score (partner→ESS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Symbiont-mediated disruption of host cellular anatomical structure →	+0.169	+0.875	<.001	.001	3	18
KIDNEY	Symbiont-mediated disruption of host anatomical structure →	+0.169	+0.875	<.001	.001	3	18
KIDNEY	Interleukin-34-mediated signaling pathway →	+0.249	+0.710	.002	.001	3	15
KIDNEY	Regulation of Golgi inheritance →	+0.167	+0.655	.001	.008	2	14
LARGE_INTESTINE	Positive regulation of macrophage proliferation →	+0.175	+0.889	<.001	<.001	3	13
URINARY_TRACT	Protein to membrane docking →	+0.128	+1.188	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,409 associations by consensus.

Symbiont-mediated disruption of host cellular anatomical structure by ESS2 expression — KIDNEY

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