ESS2

Across TCGA cell cohorts, ESS2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible ESS2-associated genes across cancer lineages are LYPD4, LYZL4, and USP17L13. Each is linked with ESS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESS2-to-partner and partner-to-ESS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYPD4 grouped by ESS2-low versus ESS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESS2→partner) and Y-score (partner→ESS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYPD4 →	+0.055	+3.920	.001	.005	3	1
OVARY	LYZL4 →	+0.136	+3.938	<.001	.005	3	1
OVARY	USP17L13 →	+0.008	+4.222	<.001	.006	3	1
OVARY	USP17L17 →	+0.008	+4.222	<.001	.006	3	1
OVARY	KRT33A →	+0.034	+4.643	<.001	<.001	3	1
OVARY	AFM →	+0.064	+3.700	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

LYPD4 by ESS2 expression — LARGE_INTESTINE

Explore this box plot interactively →