Across TCGA patient cohorts, ESRRG mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESRRG-associated genes across cancer lineages are ATM, 4E-BP1_pT70, and cIAP. Each is linked with ESRRG in more than 2 cancer types. Because this analysis shows association rather than direction, both ESRRG-to-partner and partner-to-ESRRG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESRRG→partner) and Y-score (partner→ESRRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.835	-3.161	<.001	.019	3	3
COAD	4E-BP1_pT70 →	+0.184	+3.178	.001	.010	3	3
COAD	cIAP →	+0.142	+2.820	.023	.035	3	3
UCEC	Caspase-7-cleavedD198 →	+0.393	+1.505	.032	.034	3	3
LUSC	Smad3 →	+0.102	+2.548	.005	<.001	3	2
COAD	PCNA →	+0.320	+3.178	.008	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

ESRRG survival (RNA) · tumor vs normal (RNA) · all ESRRG data types