ESRRA

Across TCGA cell cohorts, ESRRA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,033 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ESRRA-associated GO terms across cancer lineages are Transcription pausing by RNA polymerase II, Ribosomal large subunit assembly, and Mitochondrial potassium ion transmembrane transport. Each is linked with ESRRA in more than 10 cancer types. Because this analysis shows association rather than direction, both ESRRA-to-partner and partner-to-ESRRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription pausing by RNA polymerase II grouped by ESRRA-low versus ESRRA-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ESRRA→partner) and Y-score (partner→ESRRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Transcription pausing by RNA polymerase II →	+0.152	+0.794	<.001	<.001	3	11
LARGE_INTESTINE	Ribosomal large subunit assembly →	+0.107	+0.561	<.001	.002	3	10
SKIN	Mitochondrial potassium ion transmembrane transport →	+0.143	+0.802	<.001	<.001	3	10
STOMACH	CAMKK-AMPK signaling cascade →	+0.131	+0.891	.006	<.001	3	10
LARGE_INTESTINE	Mitochondrial ribosome assembly →	+0.096	+0.518	<.001	.003	3	9
BONE	CAAX-box protein processing →	+0.149	+0.930	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,033 associations by consensus.

Transcription pausing by RNA polymerase II by ESRRA expression — BONE

Explore this box plot interactively →