ESRRA

Across TCGA cell cohorts, ESRRA mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ESRRA-associated genes across cancer lineages are PPY, AKR1D1, and GJA10. Each is linked with ESRRA in more than 1 cancer types. Because this analysis shows association rather than direction, both ESRRA-to-partner and partner-to-ESRRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPY grouped by ESRRA-low versus ESRRA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESRRA→partner) and Y-score (partner→ESRRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPY →	+0.364	+3.920	<.001	.005	3	1
LARGE_INTESTINE	AKR1D1 →	+0.364	+3.914	<.001	.005	3	1
LARGE_INTESTINE	GJA10 →	+0.069	+4.217	<.001	.001	3	1
LARGE_INTESTINE	PTH →	+0.073	+5.099	<.001	<.001	3	1
LARGE_INTESTINE	TEX55 →	+0.015	+3.684	.002	.006	3	1
LARGE_INTESTINE	RSPO1 →	+0.028	+4.217	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PPY by ESRRA expression — LARGE_INTESTINE

Explore this box plot interactively →