ESRP2

Across TCGA patient cohorts, ESRP2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESRP2-associated genes across cancer lineages are ATM, EGFR_pY1068, and A-Raf_pS299. Each is linked with ESRP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ESRP2-to-partner and partner-to-ESRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ESRP2-low versus ESRP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESRP2→partner) and Y-score (partner→ESRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.326	-1.321	.032	.029	3	4
UCEC	EGFR_pY1068 →	-0.170	-1.584	.043	.009	3	1
UCEC	A-Raf_pS299 →	-0.101	-1.678	.011	.021	3	1
UCEC	FOXO3a_pS318_S321 →	-0.086	-1.492	.039	.027	3	1
UCEC	MEK1 →	+0.267	+1.440	.029	.022	3	1
UCEC	MSH6 →	-0.313	-2.000	.004	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by ESRP2 expression — UCEC

Explore this box plot interactively →