ESRP2

Across TCGA cell cohorts, ESRP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,801 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ESRP2-associated GO terms across cancer lineages are Negative regulation of Arp2/3 complex-mediated actin nucleation, Basolateral protein secretion, and Cellular response to indole-3-methanol. Each is linked with ESRP2 in more than 12 cancer types. Because this analysis shows association rather than direction, both ESRP2-to-partner and partner-to-ESRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Arp2/3 complex-mediated actin nucleation grouped by ESRP2-low versus ESRP2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ESRP2→partner) and Y-score (partner→ESRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.200	+1.957	<.001	<.001	3	13
STOMACH	Basolateral protein secretion →	+0.219	+2.364	<.001	<.001	3	12
PANCREAS	Cellular response to indole-3-methanol →	+0.251	+2.300	<.001	<.001	3	12
OVARY	Bundle of His cell-Purkinje myocyte adhesion involved in cell communication →	+0.581	+2.494	.005	<.001	3	12
LIVER	L-leucine transport →	+0.195	+2.253	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Response to molecule of fungal origin →	+1.605	+2.388	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,801 associations by consensus.

Negative regulation of Arp2/3 complex-mediated actin nucleation by ESRP2 expression — PANCREAS

Explore this box plot interactively →