ESRP1

Across TCGA pan-cancer cohorts, ESRP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ESRP1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ESRP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ESRP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where ESRP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.873	0.588	.004	16	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.854	.016	6	view →
CCRCC	OS	Median	All	1.000	0.545	.002	5	view →
PDAC	DFS	Tertile	IV	0.558	0.225	.024	4	view →
UCEC	DFS	Quartile	II,III,IV	0.873	0.307	.047	4	view →
LSCC	DFS	Median	II,III,IV	0.451	0.877	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ESRP1–HNSC (DFS)

Open the HNSC breakdown →