ESRP1

Across TCGA cell cohorts, ESRP1 mutation is significantly associated with the RNA expression of many other genes, with 1,822 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ESRP1-associated genes across cancer lineages are SH3GL2, CCDC110, and DCLK2. Each is linked with ESRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESRP1-to-partner and partner-to-ESRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by ESRP1-low versus ESRP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESRP1→partner) and Y-score (partner→ESRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+0.783	+2.252	.009	.004	3	2
BLOOD_Leukemia	CCDC110 →	+0.516	+3.440	.002	.006	3	2
BLOOD_Leukemia	DCLK2 →	+0.993	+3.346	<.001	.008	3	2
BLOOD_Lymphoma	BMP15 →	+0.021	+4.643	<.001	.005	3	2
BLOOD_Lymphoma	OR6J1 →	+0.004	+4.643	<.001	.005	3	2
LARGE_INTESTINE	CCNP →	+0.957	+2.265	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,822 associations by consensus.

SH3GL2 by ESRP1 expression — LARGE_INTESTINE

Explore this box plot interactively →