ESR2

Across TCGA cell cohorts, ESR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,566 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ESR2-associated GO terms across cancer lineages are Recombinational repair, Subtelomeric heterochromatin formation, and Double-strand break repair. Each is linked with ESR2 in more than 12 cancer types. Because this analysis shows association rather than direction, both ESR2-to-partner and partner-to-ESR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Recombinational repair grouped by ESR2-low versus ESR2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ESR2→partner) and Y-score (partner→ESR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Recombinational repair →	+0.084	+0.205	<.001	.002	3	13
BONE	Subtelomeric heterochromatin formation →	+0.112	+0.327	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair →	+0.074	+0.333	<.001	<.001	3	12
PANCREAS	DNA recombination →	+0.083	+0.226	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via homologous recombination →	+0.071	+0.314	.003	.002	2	13
BONE	DNA integrity checkpoint signaling →	+0.113	+0.597	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,566 associations by consensus.

Recombinational repair by ESR2 expression — PANCREAS

Explore this box plot interactively →