ESR2

Across TCGA cell cohorts, ESR2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ESR2-associated genes across cancer lineages are PRH2, TSLP, and POU3F2. Each is linked with ESR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESR2-to-partner and partner-to-ESR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRH2 grouped by ESR2-low versus ESR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESR2→partner) and Y-score (partner→ESR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRH2 →	+0.138	+3.678	<.001	.002	3	1
LARGE_INTESTINE	TSLP →	+0.601	+3.273	<.001	.006	3	1
LARGE_INTESTINE	POU3F2 →	+0.466	+3.442	<.001	.005	3	1
LARGE_INTESTINE	HMX3 →	+0.596	+3.531	<.001	.007	3	1
LARGE_INTESTINE	TMEM233 →	+0.220	+2.933	.005	.003	3	1
BLOOD_Lymphoma	OXT →	+0.053	+3.523	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PRH2 by ESR2 expression — LARGE_INTESTINE

Explore this box plot interactively →