ESPNP

Across TCGA pan-cancer cohorts, ESPNP RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated ESPNP data layer compared with 1 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ESPNP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ESPNP expression acts as an unfavorable survival marker, although some lineages such as KIRP and LUAD show a favorable association.

ACC, KIRP, and LUAD are the cancer types where ESPNP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Quartile	All	0.571	0.955	<.001	102	view →
KIRP	DFS	Median	All	1.000	0.780	.001	70	view →
LUAD	OS	Median	All	0.857	0.707	<.001	45	view →
UCEC	DFS	Quartile	All	0.738	0.849	.006	40	view →
UCS	OS	Quartile	III,IV	0.642	0.174	.010	32	view →
CHOL	DFS	Median	II,III,IV	0.121	0.626	.002	24	view →
KIRC	OS	Tertile	All	0.897	0.813	.003	19	view →
THCA	DFS	Median	II,III,IV	0.794	0.926	.009	13	view →
LIHC	OS	Tertile	All	0.727	0.484	.004	11	view →
PRAD	OS	Quartile	All	0.981	1.000	.023	8	view →
DLBC	OS	Median	IV	0.342	0.930	.045	6	view →
STAD	DFS	Median	III,IV	0.700	0.493	.025	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

ESPNP–ACC (OS)

Open the ACC breakdown →