ESPNL

Across TCGA patient cohorts, ESPNL RNA expression is significantly associated with the go_rna of many other GO terms, with 7,066 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ESPNL-associated GO terms across cancer lineages are Neural tube development, Viral gene expression, and Negative regulation of cell growth. Each is linked with ESPNL in more than 18 cancer types. Because this analysis shows association rather than direction, both ESPNL-to-partner and partner-to-ESPNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neural tube development grouped by ESPNL-low versus ESPNL-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ESPNL→partner) and Y-score (partner→ESPNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Neural tube development →	+0.041	+0.466	<.001	<.001	3	19
ESCA	Viral gene expression →	+0.052	+0.582	.003	<.001	3	17
STAD	Negative regulation of cell growth →	+0.042	+0.350	<.001	<.001	3	17
STAD	Cytoplasmic sequestering of transcription factor →	+0.056	+0.428	<.001	<.001	3	17
STAD	Mitochondrial ribosome assembly →	+0.040	+0.551	<.001	<.001	3	16
STAD	Import into nucleus →	+0.033	+0.419	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,066 associations by consensus.

Neural tube development by ESPNL expression — STAD

Explore this box plot interactively →