ESPNL

Across TCGA patient cohorts, ESPNL protein abundance is significantly associated with the RNA expression of many other genes, with 750 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible ESPNL-associated genes across cancer lineages are SNRNP27, ACTR10, and SHLD3. Each is linked with ESPNL in more than 1 cancer types. Because this analysis shows association rather than direction, both ESPNL-to-partner and partner-to-ESPNL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ESPNL versus SNRNP27 in BRCA, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESPNL→partner) and Y-score (partner→ESPNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SNRNP27 →	+0.507	+0.836	.002	.001	3	2
BRCA	ACTR10 →	+0.879	+0.821	<.001	<.001	3	2
BRCA	SHLD3 →	+0.613	+0.899	<.001	<.001	3	2
OV	CBX7 →	-0.786	-0.636	.003	<.001	3	1
OV	SYNGR1 →	-1.633	-0.596	<.001	<.001	3	1
OV	PTPRZ1 →	-0.709	-0.720	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 750 associations by consensus.

ESPNL vs SNRNP27 — BRCA

Explore this scatter interactively →