ESPNL

Across TCGA patient cohorts, ESPNL mutation is significantly associated with the RNA expression of many other genes, with 1,616 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESPNL-associated genes across cancer lineages are DNMT1, RSL24D1P5, and RNU4-50P. Each is linked with ESPNL in more than 2 cancer types. Because this analysis shows association rather than direction, both ESPNL-to-partner and partner-to-ESPNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNMT1 grouped by ESPNL-low versus ESPNL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESPNL→partner) and Y-score (partner→ESPNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DNMT1 →	+0.724	+3.633	<.001	.001	3	3
LUSC	RSL24D1P5 →	+0.046	+3.792	.009	.002	3	3
READ	RNU4-50P →	+0.314	+4.937	.001	.002	3	2
READ	RNU1-57P →	+0.259	+4.421	.001	.009	3	2
READ	RNGTTP1 →	+0.087	+4.421	<.001	.009	3	2
READ	UCHL1-AS1 →	+0.058	+4.421	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,616 associations by consensus.

DNMT1 by ESPNL expression — UCEC

Explore this box plot interactively →