ESPNL

Across TCGA patient cohorts, ESPNL mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESPNL-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and EGFR. Each is linked with ESPNL in more than 2 cancer types. Because this analysis shows association rather than direction, both ESPNL-to-partner and partner-to-ESPNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ESPNL-low versus ESPNL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESPNL→partner) and Y-score (partner→ESPNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.947	+3.604	<.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.241	-2.321	.028	.034	3	1
UCEC	EGFR →	-0.169	-3.000	.015	.036	3	1
UCEC	A-Raf_pS299 →	-0.214	-3.459	<.001	.005	3	1
UCEC	Fibronectin →	-0.376	-2.449	.009	.019	3	1
UCEC	HSP70 →	-0.362	-2.312	.039	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Caspase-7-cleavedD198 by ESPNL expression — UCEC

Explore this box plot interactively →