ESPNL

Across TCGA cell cohorts, ESPNL RNA expression is significantly associated with the go_rna of many other GO terms, with 2,406 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ESPNL-associated GO terms across cancer lineages are Regulation of nucleotide-excision repair, Nucleic acid transport, and RNA transport. Each is linked with ESPNL in more than 6 cancer types. Because this analysis shows association rather than direction, both ESPNL-to-partner and partner-to-ESPNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nucleotide-excision repair grouped by ESPNL-low versus ESPNL-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ESPNL→partner) and Y-score (partner→ESPNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of nucleotide-excision repair →	+0.123	+1.371	<.001	.001	3	6
SOFT_TISSUE	Nucleic acid transport →	+0.073	+0.710	<.001	.001	3	6
SOFT_TISSUE	RNA transport →	+0.073	+0.710	<.001	.001	3	6
BLOOD_Leukemia	Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.069	+0.327	<.001	.008	2	7
SOFT_TISSUE	Establishment of RNA localization →	+0.068	+0.784	<.001	<.001	3	6
BLOOD_Lymphoma	Transcription initiation at RNA polymerase II promoter →	+0.033	+0.633	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,406 associations by consensus.

Regulation of nucleotide-excision repair by ESPNL expression — BONE

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