ESPNL

Across TCGA cell cohorts, ESPNL mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ESPNL-associated genes across cancer lineages are OR12D2, SLC4A1, and TEX13B. Each is linked with ESPNL in more than 1 cancer types. Because this analysis shows association rather than direction, both ESPNL-to-partner and partner-to-ESPNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D2 grouped by ESPNL-low versus ESPNL-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESPNL→partner) and Y-score (partner→ESPNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR12D2 →	+0.030	+3.635	<.001	.007	3	2
LARGE_INTESTINE	SLC4A1 →	+0.032	+3.144	.001	.001	3	2
LUNG_SCLC	TEX13B →	+0.128	+3.710	<.001	.008	3	2
LUNG_SCLC	GAGE12H →	+1.759	+4.070	<.001	.003	3	2
LUNG_NSCLC_LUAD	ANKRD34C →	+0.043	+3.628	.004	.002	3	2
SOFT_TISSUE	OR5AC1 →	+0.010	+4.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

OR12D2 by ESPNL expression — SOFT_TISSUE

Explore this box plot interactively →