ESF1

Across TCGA cell cohorts, ESF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,564 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ESF1-associated GO terms across cancer lineages are DNA-templated transcription termination, Regulation of transcription by RNA polymerase III, and Transcription by RNA polymerase III. Each is linked with ESF1 in more than 15 cancer types. Because this analysis shows association rather than direction, both ESF1-to-partner and partner-to-ESF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription termination grouped by ESF1-low versus ESF1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ESF1→partner) and Y-score (partner→ESF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DNA-templated transcription termination →	+0.103	+0.855	.001	.003	3	16
BREAST	Regulation of transcription by RNA polymerase III →	+0.061	+0.545	<.001	<.001	3	15
LARGE_INTESTINE	Transcription by RNA polymerase III →	+0.082	+0.716	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Transcription initiation at RNA polymerase I promoter →	+0.100	+0.845	.007	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication →	+0.102	+0.851	.001	<.001	3	14
BONE	Ribosome biogenesis →	+0.119	+0.653	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,564 associations by consensus.

DNA-templated transcription termination by ESF1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →