ESCO2

Across TCGA patient cohorts, ESCO2 mutation is significantly associated with the RNA expression of many other genes, with 2,221 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESCO2-associated genes across cancer lineages are ZNF736P7Y, PPP1R12BP1, and ZNF833P. Each is linked with ESCO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ESCO2-to-partner and partner-to-ESCO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF736P7Y grouped by ESCO2-low versus ESCO2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESCO2→partner) and Y-score (partner→ESCO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ZNF736P7Y →	+0.062	+3.621	<.001	.006	3	3
CESC	PPP1R12BP1 →	+0.019	+4.969	<.001	.004	3	2
CESC	ZNF833P →	+0.034	+4.996	.003	.002	3	2
LUSC	MIR8053 →	+0.612	+5.474	<.001	.005	3	2
UCEC	PHF5A →	+0.571	+3.523	<.001	<.001	3	2
UCEC	RNF167 →	+0.334	+2.542	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,221 associations by consensus.

ZNF736P7Y by ESCO2 expression — STAD

Explore this box plot interactively →