ESCO2

Across TCGA patient cohorts, ESCO2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESCO2-associated genes across cancer lineages are TFRC, ASNS, and eEF2. Each is linked with ESCO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ESCO2-to-partner and partner-to-ESCO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by ESCO2-low versus ESCO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESCO2→partner) and Y-score (partner→ESCO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.854	+2.502	<.001	.002	3	2
COAD	ASNS →	+0.831	+2.815	<.001	.036	3	2
UCEC	eEF2 →	+0.369	+2.000	.008	.010	3	2
UCEC	FASN →	+0.425	+1.584	.005	.036	3	2
UCEC	PCNA →	+0.297	+3.807	<.001	<.001	2	3
UCEC	Di-Ras3 →	-0.181	-3.459	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

TFRC by ESCO2 expression — UCEC

Explore this box plot interactively →