ESCO1

Across TCGA pan-cancer cohorts, ESCO1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ESCO1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ESCO1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ESCO1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, UCEC, and PDAC are the cancer types where ESCO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.858	0.524	.005	25	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.583	.020	24	view →
PDAC	DFS	Median	All	0.293	0.654	.002	13	view →
LUAD	DFS	Quartile	III,IV	0.733	0.323	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ESCO1–LSCC (DFS)

Open the LSCC breakdown →