ESCO1

Across TCGA patient cohorts, ESCO1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESCO1-associated genes across cancer lineages are Notch1, JNK_pT183_Y185, and JNK2. Each is linked with ESCO1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ESCO1-to-partner and partner-to-ESCO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ESCO1-low versus ESCO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESCO1→partner) and Y-score (partner→ESCO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.132	+2.428	.002	.001	3	4
UCEC	JNK_pT183_Y185 →	-0.179	-1.879	<.001	<.001	3	2
UCEC	JNK2 →	+0.260	+1.893	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.449	-1.401	.001	.010	3	2
UCEC	PDCD4 →	-0.378	-1.201	.009	.028	3	2
UCEC	Smad3 →	+0.092	+1.807	.048	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Notch1 by ESCO1 expression — UCEC

Explore this box plot interactively →