ESCO1

Across TCGA cell cohorts, ESCO1 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ESCO1-associated genes across cancer lineages are KRTAP2-2, CRYGD, and PRR20B. Each is linked with ESCO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESCO1-to-partner and partner-to-ESCO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP2-2 grouped by ESCO1-low versus ESCO1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESCO1→partner) and Y-score (partner→ESCO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KRTAP2-2 →	+0.062	+4.614	<.001	.004	3	1
LUNG_NSCLC_LUAD	CRYGD →	+0.037	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20B →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20A →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20D →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20E →	+0.036	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

KRTAP2-2 by ESCO1 expression — PANCREAS

Explore this box plot interactively →