ESAM

Across TCGA pan-cancer cohorts, ESAM mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ESAM data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ESAM mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ESAM expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where ESAM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.684	0.350	.008	17	view →
PDAC	OS	Tertile	III,IV	0.387	0.977	.005	13	view →
LUAD	OS	Tertile	All	0.574	0.874	.022	4	view →
LSCC	DFS	Median	All	0.894	0.518	.032	1	view →
HNSC	OS	Median	III,IV	0.930	0.828	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ESAM–CCRCC (DFS)

Open the CCRCC breakdown →