ESAM

Across TCGA patient cohorts, ESAM protein abundance is significantly associated with the RNA expression of many other genes, with 13,367 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible ESAM-associated genes across cancer lineages are DIPK2B, MYCT1, and BCL6B. Each is linked with ESAM in more than 9 cancer types. Because this analysis shows association rather than direction, both ESAM-to-partner and partner-to-ESAM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ESAM versus DIPK2B in CCRCC, with a Pearson correlation of 0.76.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESAM→partner) and Y-score (partner→ESAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DIPK2B →	+1.220	+0.652	<.001	<.001	3	10
CCRCC	MYCT1 →	+1.207	+0.631	<.001	<.001	3	8
CCRCC	BCL6B →	+1.273	+0.595	<.001	<.001	3	8
CCRCC	ADGRL4 →	+1.005	+0.566	<.001	<.001	3	8
CCRCC	ARHGEF15 →	+0.975	+0.562	<.001	<.001	3	8
CCRCC	TIE1 →	+1.097	+0.604	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,367 associations by consensus.

ESAM vs DIPK2B — CCRCC

Explore this scatter interactively →