ESAM

Across TCGA patient cohorts, ESAM mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESAM-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and ACC1. Each is linked with ESAM in more than 1 cancer types. Because this analysis shows association rather than direction, both ESAM-to-partner and partner-to-ESAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ESAM-low versus ESAM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESAM→partner) and Y-score (partner→ESAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.312	-3.087	.002	<.001	3	1
UCEC	A-Raf_pS299 →	-0.156	-3.700	.001	.001	3	1
UCEC	ACC1 →	+0.303	+2.820	.038	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.220	-3.074	.001	<.001	3	1
UCEC	JNK2 →	+0.252	+2.009	.001	.017	3	1
UCEC	Notch1 →	+0.163	+2.415	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by ESAM expression — UCEC

Explore this box plot interactively →