ESAM

Across TCGA cell cohorts, ESAM RNA expression is significantly associated with the go_rna of many other GO terms, with 2,937 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ESAM-associated GO terms across cancer lineages are Negative regulation of response to type II interferon, Negative regulation of type II interferon-mediated signaling pathway, and Glycoside catabolic process. Each is linked with ESAM in more than 6 cancer types. Because this analysis shows association rather than direction, both ESAM-to-partner and partner-to-ESAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of response to type II interferon grouped by ESAM-low versus ESAM-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ESAM→partner) and Y-score (partner→ESAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of response to type II interferon →	+0.141	+1.382	.001	.003	3	7
URINARY_TRACT	Negative regulation of type II interferon-mediated signaling pathway →	+0.141	+1.382	.001	.003	3	7
OESOPHAGUS	Glycoside catabolic process →	+0.158	+1.561	<.001	.002	3	7
URINARY_TRACT	Phospholipid biosynthetic process →	+0.040	+1.916	<.001	<.001	3	6
STOMACH	Regulation of interleukin-10 production →	+0.155	+1.985	.002	.001	3	6
SOFT_TISSUE	Plasmacytoid dendritic cell activation →	-0.140	-0.997	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,937 associations by consensus.

Negative regulation of response to type II interferon by ESAM expression — URINARY_TRACT

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