ESAM

Across TCGA cell cohorts, ESAM mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ESAM-associated genes across cancer lineages are CYP4A11 and FAM205A. Each is linked with ESAM in more than 1 cancer types. Because this analysis shows association rather than direction, both ESAM-to-partner and partner-to-ESAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP4A11 grouped by ESAM-low versus ESAM-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESAM→partner) and Y-score (partner→ESAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CYP4A11 →	+0.855	+4.129	.001	.007	3	1
LARGE_INTESTINE	FAM205A →	+0.030	+4.614	<.001	.002	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CYP4A11 by ESAM expression — STOMACH

Explore this box plot interactively →