ERVK-28

Across TCGA pan-cancer cohorts, ERVK-28 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ERVK-28 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher ERVK-28 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ERVK-28 expression acts as an unfavorable survival marker, although some lineages such as UCS and OV show a favorable association.

UCS, MESO, and KICH are the cancer types where ERVK-28 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	III,IV	0.596	0.200	<.001	102	view →
MESO	OS	Tertile	IV	0.203	0.661	.003	75	view →
KICH	DFS	Quartile	All	0.506	0.963	<.001	61	view →
OV	OS	Median	III,IV	0.867	0.814	.009	50	view →
SKCM	OS	Median	II,III,IV	0.281	0.494	<.001	41	view →
THCA	DFS	Median	IV	0.439	0.958	<.001	28	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
UCEC	DFS	Tertile	All	0.859	0.906	.003	24	view →
CESC	DFS	Tertile	All	0.792	0.495	.029	18	view →
LGG	OS	Quartile	All	0.906	0.767	.001	16	view →
LUSC	DFS	Quartile	III,IV	0.387	0.691	.008	15	view →
STAD	OS	Quartile	II,III,IV	0.301	0.597	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ERVK-28–UCS (DFS)

Open the UCS breakdown →