ERVH-1

Across TCGA pan-cancer cohorts, ERVH-1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ERVH-1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ERVH-1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ERVH-1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and BLCA show a favorable association.

KIRP, LUSC, and BLCA are the cancer types where ERVH-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	III,IV	0.841	0.134	.002	50	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	38	view →
BLCA	OS	Tertile	All	0.901	0.350	.018	36	view →
BRCA	OS	Tertile	IV	0.169	0.828	<.001	36	view →
MESO	OS	Median	IV	0.820	0.395	.014	32	view →
UCEC	DFS	Tertile	All	0.770	0.865	.002	32	view →
KIRC	OS	Tertile	All	0.762	0.564	.001	25	view →
THYM	OS	Tertile	All	0.696	0.977	.003	24	view →
OV	DFS	Median	II,III,IV	0.129	0.180	.017	22	view →
UCS	DFS	Median	III,IV	0.150	0.438	.021	14	view →
PAAD	OS	Tertile	II,III,IV	0.542	0.330	.020	12	view →
KICH	DFS	Median	II,III,IV	0.709	0.961	.011	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ERVH-1–KIRP (OS)

Open the KIRP breakdown →