ERVE-1

Across TCGA pan-cancer cohorts, ERVE-1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ERVE-1 data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ERVE-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ERVE-1 expression acts as an unfavorable survival marker, although some lineages such as LGG and UVM show a favorable association.

KIRC, LGG, and UVM are the cancer types where ERVE-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	II,III,IV	0.680	0.844	.002	67	view →
LGG	DFS	Quartile	All	0.636	0.371	<.001	38	view →
UVM	DFS	Tertile	II,III,IV	1.000	0.505	.032	27	view →
BLCA	DFS	Median	II,III,IV	0.667	0.562	.008	27	view →
SKCM	DFS	Quartile	III,IV	0.374	0.698	.002	25	view →
PAAD	DFS	Quartile	All	0.197	0.478	.006	24	view →
CESC	DFS	Median	All	0.764	0.877	.004	16	view →
KIRP	DFS	Median	III,IV	0.801	0.156	.008	14	view →
HNSC	OS	Tertile	All	0.802	0.698	.023	12	view →
LUAD	OS	Tertile	All	0.863	0.717	.016	10	view →
PCPG	DFS	Tertile	All	0.586	0.874	.049	9	view →
READ	DFS	Quartile	II,III,IV	0.750	0.313	.023	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ERVE-1–KIRC (DFS)

Open the KIRC breakdown →