ERRFI1

Across TCGA patient cohorts, ERRFI1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERRFI1-associated genes across cancer lineages are 4E-BP1, MEK1, and PDCD4. Each is linked with ERRFI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERRFI1-to-partner and partner-to-ERRFI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ERRFI1-low versus ERRFI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERRFI1→partner) and Y-score (partner→ERRFI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.378	+2.837	.007	.035	3	2
UCEC	MEK1 →	+0.558	+3.000	.003	.036	3	1
UCEC	PDCD4 →	-0.675	-3.321	.006	.010	3	1
UCEC	Shc_pY317 →	-0.242	-3.321	.002	.010	3	1
UCEC	STAT3_pY705 →	-0.522	-3.159	<.001	.019	3	1
UCEC	Bcl-xL →	+0.179	+3.321	.033	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

4E-BP1 by ERRFI1 expression — UCEC

Explore this box plot interactively →