ERP27

Across TCGA patient cohorts, ERP27 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERP27-associated genes across cancer lineages are EGFR_pY1068, MSH2, and Notch1. Each is linked with ERP27 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERP27-to-partner and partner-to-ERP27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ERP27-low versus ERP27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERP27→partner) and Y-score (partner→ERP27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.283	-2.321	.024	.035	3	1
UCEC	MSH2 →	-0.325	-2.321	.005	.035	3	1
UCEC	Notch1 →	+0.283	+2.321	<.001	.035	3	1
UCEC	STAT3_pY705 →	-0.566	-3.459	<.001	.005	3	1
UCEC	ATM →	-0.660	-3.459	.003	.005	3	1
UCEC	Caspase-8 →	-0.282	-3.143	.025	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by ERP27 expression — UCEC

Explore this box plot interactively →