ERO1B

Across TCGA patient cohorts, ERO1B mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERO1B-associated genes across cancer lineages are ERK2, TIGAR, and 14-3-3_beta. Each is linked with ERO1B in more than 1 cancer types. Because this analysis shows association rather than direction, both ERO1B-to-partner and partner-to-ERO1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ERO1B-low versus ERO1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERO1B→partner) and Y-score (partner→ERO1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.166	+1.906	.032	.016	3	2
UCEC	TIGAR →	+0.158	+2.441	.009	.001	3	2
UCEC	14-3-3_beta →	-0.099	-3.143	.014	.018	3	1
UCEC	EGFR_pY1068 →	-0.321	-2.700	.001	.006	3	1
UCEC	eIF4E →	+0.228	+3.584	.007	.002	2	2
UCEC	A-Raf_pS299 →	-0.174	-3.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ERK2 by ERO1B expression — UCEC

Explore this box plot interactively →