ERO1B

Across TCGA cell cohorts, ERO1B mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERO1B-associated genes across cancer lineages are C7orf77, KLHL40, and CST9. Each is linked with ERO1B in more than 1 cancer types. Because this analysis shows association rather than direction, both ERO1B-to-partner and partner-to-ERO1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C7orf77 grouped by ERO1B-low versus ERO1B-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERO1B→partner) and Y-score (partner→ERO1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C7orf77 →	+0.036	+4.643	<.001	.008	3	1
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	1
BLOOD_Lymphoma	CST9 →	+0.060	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	CYLC1 →	+0.029	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

C7orf77 by ERO1B expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →