ERN2

Across TCGA pan-cancer cohorts, ERN2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ERN2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ERN2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ERN2 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and PDAC are the cancer types where ERN2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERN2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.334	<.001	8	view →
HNSC	All	III,IV	−0.927	.001	6	view →
PDAC	All	All	+0.473	.015	4	view →
LUAD	All	III,IV	+0.603	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ERN2–COAD

Open the COAD breakdown →