ERN2

Across TCGA patient cohorts, ERN2 mutation is significantly associated with the RNA expression of many other genes, with 3,505 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERN2-associated genes across cancer lineages are MIR6765, EME1, and RNU6-633P. Each is linked with ERN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ERN2-to-partner and partner-to-ERN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6765 grouped by ERN2-low versus ERN2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERN2→partner) and Y-score (partner→ERN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR6765 →	+0.482	+5.201	<.001	.007	3	4
UCEC	EME1 →	+0.520	+1.903	<.001	<.001	3	4
COAD	RNU6-633P →	+0.549	+3.467	<.001	.001	3	3
COAD	BPY2DP →	+0.128	+4.602	<.001	.003	3	3
LUAD	SEC22A →	+0.365	+3.356	.001	.005	3	3
LUAD	TK1 →	+0.828	+3.727	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,505 associations by consensus.

MIR6765 by ERN2 expression — CESC

Explore this box plot interactively →