ERN2

Across TCGA patient cohorts, ERN2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERN2-associated genes across cancer lineages are VHL, p21, and PDCD4. Each is linked with ERN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERN2-to-partner and partner-to-ERN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by ERN2-low versus ERN2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERN2→partner) and Y-score (partner→ERN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	VHL →	-0.866	-2.321	.039	.035	3	2
UCEC	p21 →	+0.167	+2.584	.015	.010	3	2
UCEC	PDCD4 →	-0.569	-1.668	<.001	.021	3	2
UCEC	ATM →	-0.489	-3.446	.002	.005	3	2
UCEC	4E-BP1_pT37_T46 →	-0.315	-3.446	.019	.005	3	2
UCEC	GAPDH →	+0.412	+1.700	.032	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

VHL by ERN2 expression — LUAD

Explore this box plot interactively →