ERN1

Across TCGA pan-cancer cohorts, ERN1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ERN1 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ERN1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ERN1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where ERN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	1.000	0.564	.001	34	view →
PDAC	DFS	Median	II,III,IV	0.675	0.269	<.001	31	view →
LUAD	DFS	Median	All	0.837	0.968	.003	13	view →
GBM	OS	Median	All	0.801	0.279	.011	11	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ERN1–HNSC (OS)

Open the HNSC breakdown →