ERN1

Across TCGA patient cohorts, ERN1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,351 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ERN1-associated proteins across cancer lineages are ANK2_S1461, AOX1, and NUCB2. Each is linked with ERN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ERN1-to-partner and partner-to-ERN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERN1 versus ANK2_S1461 in PDAC, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ERN1→partner) and Y-score (partner→ERN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ANK2_S1461 →	+0.685	+0.361	<.001	<.001	3	5
HNSC	AOX1 →	+0.653	+0.396	<.001	<.001	3	5
CCRCC	NUCB2 →	+0.394	+0.559	<.001	<.001	3	4
LSCC	VPS13C →	+0.238	+0.362	<.001	<.001	3	4
BRCA	ADH1B →	+0.886	+0.528	.001	.009	3	4
CCRCC	FKBP5 →	+0.487	+0.459	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,351 associations by consensus.

ERN1 vs ANK2_S1461 — PDAC

Explore this scatter interactively →