ERN1

Across TCGA patient cohorts, ERN1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,498 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ERN1-associated genes across cancer lineages are P4HB, ZC3H14, and APBA1. Each is linked with ERN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERN1-to-partner and partner-to-ERN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERN1 versus P4HB in GBM, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERN1→partner) and Y-score (partner→ERN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	P4HB →	+0.494	+0.427	.002	.002	3	3
GBM	ZC3H14 →	-0.528	-0.443	.008	.005	3	3
LUAD	APBA1 →	-0.353	-0.183	.004	.008	3	2
CCRCC	LMNA →	-0.932	-0.541	<.001	.003	3	2
LSCC	MYLK-AS1 →	-0.402	-0.275	.006	<.001	3	2
LSCC	RNU7-84P →	-0.681	-0.215	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,498 associations by consensus.

ERN1 vs P4HB — GBM

Explore this scatter interactively →