ERN1

Across TCGA patient cohorts, ERN1 mutation is significantly associated with the RNA expression of many other genes, with 3,623 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERN1-associated genes across cancer lineages are EIF2B2, PSMC3IP, and ADAM10. Each is linked with ERN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERN1-to-partner and partner-to-ERN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF2B2 grouped by ERN1-low versus ERN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERN1→partner) and Y-score (partner→ERN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF2B2 →	+0.405	+1.787	<.001	<.001	3	3
UCEC	PSMC3IP →	+0.781	+3.425	<.001	<.001	3	3
UCEC	ADAM10 →	+0.447	+1.754	.001	.001	3	3
UCEC	FANCI →	+0.629	+2.021	<.001	<.001	3	3
UCEC	EFL1 →	+0.396	+1.541	.002	.002	3	3
UCEC	FBXO25 →	+0.304	+2.980	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,623 associations by consensus.

EIF2B2 by ERN1 expression — UCEC

Explore this box plot interactively →