ERMAP

Across TCGA patient cohorts, ERMAP mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERMAP-associated genes across cancer lineages are Caspase-7-cleavedD198, A-Raf_pS299, and AMPK_pT172. Each is linked with ERMAP in more than 1 cancer types. Because this analysis shows association rather than direction, both ERMAP-to-partner and partner-to-ERMAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ERMAP-low versus ERMAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERMAP→partner) and Y-score (partner→ERMAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.695	+3.019	.009	.019	3	2
UCEC	A-Raf_pS299 →	-0.135	-2.000	.012	.032	3	1
UCEC	AMPK_pT172 →	+0.419	+3.169	.023	.019	3	1
UCEC	Annexin-1 →	+0.497	+2.189	.036	.034	3	1
UCEC	Tuberin →	+0.362	+2.331	.002	.019	3	1
UCEC	YAP_pS127 →	+0.301	+2.000	.039	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Caspase-7-cleavedD198 by ERMAP expression — UCEC

Explore this box plot interactively →