ERMAP

Across TCGA cell cohorts, ERMAP mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERMAP-associated genes across cancer lineages are TPD52L3, CD300H, and OR6T1. Each is linked with ERMAP in more than 1 cancer types. Because this analysis shows association rather than direction, both ERMAP-to-partner and partner-to-ERMAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPD52L3 grouped by ERMAP-low versus ERMAP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERMAP→partner) and Y-score (partner→ERMAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TPD52L3 →	+0.037	+3.514	<.001	.001	3	2
LARGE_INTESTINE	CD300H →	+0.031	+4.000	<.001	<.001	3	2
STOMACH	OR6T1 →	+0.084	+4.285	<.001	.007	3	2
STOMACH	OR6M1 →	+0.050	+4.285	<.001	.007	3	2
BLOOD_Leukemia	SRY →	+0.020	+3.874	.004	.005	3	2
BONE	PPP1R2C →	+0.173	+5.169	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

TPD52L3 by ERMAP expression — LARGE_INTESTINE

Explore this box plot interactively →