ERLIN2

Across TCGA patient cohorts, ERLIN2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERLIN2-associated genes across cancer lineages are FoxM1, S6_pS240_S244, and STAT3_pY705. Each is linked with ERLIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERLIN2-to-partner and partner-to-ERLIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by ERLIN2-low versus ERLIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERLIN2→partner) and Y-score (partner→ERLIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.210	+1.938	.013	.001	3	2
UCEC	S6_pS240_S244 →	+0.461	+3.807	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.395	-1.797	<.001	.003	3	2
UCEC	TFRC →	+0.416	+1.700	.017	.042	3	2
UCEC	14-3-3_beta →	-0.100	-2.195	.002	.009	3	1
UCEC	EGFR_pY1068 →	-0.198	-1.652	.016	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

FoxM1 by ERLIN2 expression — UCEC

Explore this box plot interactively →