ERLIN1

Across TCGA pan-cancer cohorts, ERLIN1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ERLIN1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ERLIN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ERLIN1 is over-expressed in tumor, although a few such as KICH and LIHC show the opposite, repressed pattern.

LUAD, KICH, and LIHC are the cancer types where ERLIN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERLIN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+0.871	<.001	7	view →
KICH	Female	All	−1.181	<.001	6	view →
LIHC	All	All	−0.749	<.001	5	view →
LUSC	All	All	+0.557	<.001	5	view →
STAD	All	All	+0.610	.005	4	view →
CHOL	Female	All	−1.059	.017	2	view →
PAAD	All	All	+0.664	.009	2	view →
HNSC	Male	All	+0.442	.024	2	view →
KIRP	All	All	−0.282	.036	2	view →
READ	All	II,III,IV	−0.479	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ERLIN1–LUAD

Open the LUAD breakdown →