ERLEC1

Across TCGA cell cohorts, ERLEC1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ERLEC1-associated genes across cancer lineages are HIGD1C, IQCF3, and KRTAP19-3. Each is linked with ERLEC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERLEC1-to-partner and partner-to-ERLEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIGD1C grouped by ERLEC1-low versus ERLEC1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERLEC1→partner) and Y-score (partner→ERLEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HIGD1C →	+0.088	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.049	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP19-3 →	+0.132	+5.228	<.001	.005	3	1
LARGE_INTESTINE	CCDC195 →	+0.044	+4.467	.003	.004	3	1
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

HIGD1C by ERLEC1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →