ERICH5

Across TCGA patient cohorts, ERICH5 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERICH5-associated genes across cancer lineages are Notch1, ER-alpha_pS118, and ER-alpha. Each is linked with ERICH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERICH5-to-partner and partner-to-ERICH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ERICH5-low versus ERICH5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERICH5→partner) and Y-score (partner→ERICH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.164	+3.335	.004	.005	3	2
UCEC	ER-alpha_pS118 →	-0.296	-2.321	.045	.006	3	1
UCEC	ER-alpha →	-0.742	-2.459	.028	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.165	-2.321	.017	.034	3	1
UCEC	MEK1 →	+0.490	+2.321	.001	.006	3	1
UCEC	mTOR_pS2448 →	-0.163	-3.446	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Notch1 by ERICH5 expression — UCEC

Explore this box plot interactively →