Across TCGA pan-cancer cohorts, ERICH3-AS1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ERICH3-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where ERICH3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ERICH3-AS1 is over-expressed in tumor, although a few such as UCEC and LUSC show the opposite, repressed pattern.
UCEC, LIHC, and KIRC are the cancer types where ERICH3-AS1 tumor–normal differential expression is most reproducible.